The remarks by Iran, traditional ally of Palestinian militant group Hamas, came after Israeli warplanes pounded targets in Gaza as part of a major campaign to halt rocket fire from the enclave.
“We are, unfortunately, witnessing the escalation of savage aggression by the Zionists in recent days against the innocent and defenceless people of Palestine,” ministry spokeswoman Marzieh Afkham said in her weekly briefing with reporters.
Iran calls on “Western countries and supporters of the Zionist regime (to) take firm a stance and prevent a human catastrophe and stop the attacks,” she added, while questioning an “unrealistic excuse of the kidnapping of three Zionist settlers”.
At least 28 fatalities have been reported in Gaza since the launch of Operation Protective Edge early on Tuesday, with Israel not ruling out a ground operation.
Hamas said it fired four rockets early Wednesday at Tel Aviv, 60 kilometres (37 miles) north of Gaza, setting sirens blaring across the city.
Iran supports a Palestinian state and has long been an ally of Hamas, with Israel regularly accusing Tehran of supplying the group with weapons and rockets.
Iran´s continued support for the regime of Syrian President Bashar al-Assad, however, has driven a wedge between Iran and Hamas.